Re: Anybody had luck with a High Carb Plant based diet

randy@xxxxxxx wrote:

Let me know what you think of this on Susan,

Effect of high protein vs high carbohydrate intake on insulin
sensitivity, body weight, hemoglobin A1c, and blood pressure in
patients with type 2 diabetes mellitus.Sargrad KR, Homko C, Mozzoli
M,
Boden G.
Nutrition Center, Department of Bioscience and Biotechnology, Drexel
University, Philadelphia, PA 19104, USA. ksarg...@xxxxxxxxxx

BACKGROUND: Extremely low carbohydrate/high protein diets are popular
methods of weight loss. Compliance with these diets is poor and long-
term effectiveness and the safety of these diets for patients with
type 2 diabetes is not known. OBJECTIVE: The objective of the current
study was to evaluate effects of less extreme changes in carbohydrate
or protein diets on weight, insulin sensitivity, glycemic control,
cardiovascular risk factors (blood pressure, lipid levels), and renal
function in obese inner-city patients with type 2 diabetes. DESIGN:
Study patients were admitted to the General Clinical Research Center
for 24 hours for initial tests including a hyperinsulinemic-
euglycemic
clamp (for measurement of insulin sensitivity), bioelectrical
impedance analysis (BIA) and anthropometric measurements (for
assessment of body composition), indirect calorimetry (for
measurement
of REE), electronic blood pressure monitoring, and blood chemistries
to measure blood lipids levels along with renal and hepatic
functions.
Six patients with type 2 diabetes (five women and one man) were
randomly assigned to the high-protein diet (40% carbohydrate, 30%
protein, 30% fat) and six patients (four women and two men) to the
high-carbohydrate diet (55% carbohydrate, 15% protein, 30% fat). All
patients returned to the General Clinical Research Center weekly for
monitoring of food records; dietary compliance; and measurements of
body weight, blood pressure, and blood glucose. After 8 weeks on
these
diets, all patients were readmitted to the General Clinical Research
Center for the same series of tests. INTERVENTION: Twelve study
patients were taught to select either the high-protein or high-
carbohydrate diet and were followed for 8 weeks. MAIN OUTCOME
MEASURES: Insulin sensitivity, hemoglobin A1c, weight, and blood
pressure were measured. STATISTICAL ANALYSES: Statistical
significance
was assessed using two-tailed Student's t tests and two-way repeated
measures analysis of variance. RESULTS: Both the high-carbohydrate
and
high-protein groups lost weight (-2.2+/-0.9 kg, -2.5+/-1.6 kg,
respectively, P <.05) and the difference between the groups was not
significant (P =.9). In the high-carbohydrate group, hemoglobin A1c
decreased (from 8.2% to 6.9%, P <.03), fasting plasma glucose
decreased (from 8.8 to 7.2 mmol/L, P <.02), and insulin sensitivity
increased (from 12.8 to 17.2 micromol/kg/min, P <.03). No significant
changes in these parameters occurred in the high-protein group,
instead systolic and diastolic blood pressures decreased (-10.5+/-2.3
mm Hg, P =.003 and -18+/-9.0 mm Hg, P <.05, respectively). After 2
months on these hypocaloric diets, each diet had either no or minimal
effects on lipid levels (total cholesterol, low-density lipoprotein,
high-density lipoprotein), renal (blood urea nitrogen, serum
creatinine), or hepatic function (aspartate aminotransferase, alanine
aminotransferase, bilirubin).
PMID: 15800559 [PubMed - indexed for MEDLINE]




Randy,

I'm not Susan, and unlike some others, I don't even play her on this newsgroup.

First, read the BACKGROUND statement with a critical eye. It might reveal an agenda. Hint: "extreme", "poor compliance".

Second, look at the scope. Twelve people. Eight weeks.

Third, look at the method. The difference is between 55% and 40% carbs. If it was a 2000 kcal diet (not specified), then the difference was between 200g and 275g per day. Hardly low carb, and certainly nothing close to the term "extremely" used in the BACKGROUND.

Last, look at the RESULTS. Not much difference. We spent your money, and can truthfully say we are now published, but unfortunately we didn't discover anything. Pay no attention to the man behind the curtain.

You have a penchant for finding yawner research, Randy. I'd point out some of the credible low carb research that is emerging, but that would only cause some here to wet their shoes again.

Jim
.

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