Re: ACE inhibition by Ramipril fails at DM prevention, is slight help in lowering post glucose load glycemia

Susan <nevermind@xxxxxxxxxx> wrote:
||
|| http://content.nejm.org/cgi/reprint/NEJMe068213v1.pdf
||
|||| Results The incidence of the primary outcome did not differ
|| significantly between the ramipril group (18.1%) and the
|| placebo group (19.5%; hazard ratio for the ramipril group,
|| 0.91; 95% confidence interval [CI], 0.81 to 1.03; P=0.15).
|| Participants receiving ramipril were more likely to have
|| regression to normoglycemia than those receiving placebo
|| (hazard ratio, 1.16; 95% CI, 1.07 to 1.27; P=0.001). At the
|| end of the study, the median fasting plasma glucose level was
|| not significantly lower in the ramipril group (102.7 mg per
|| deciliter [5.70 mmol per liter]) than in the placebo group
|| (103.4 mg per deciliter [5.74 mmol per liter], P=0.07),
|| though plasma glucose levels 2 hours after an oral glucose
|| load were significantly lower in the ramipril group (135.1 mg
|| per deciliter [7.50 mmol per liter] vs. 140.5 mg per
|| deciliter [7.80 mmol per liter], P=0.01).
||
|| Conclusions Among persons with impaired fasting glucose
|| levels or impaired glucose tolerance, the use of ramipril for
|| 3 years does not significantly reduce the incidence of
|| diabetes or death but does significantly increase regression
|| to normoglycemia. (ClinicalTrials.gov number, NCT00095654.)<<
||
||
|| Susan

I was under the impression that the reason for using Ramipril
was
a reduction in the incidence of renal, heart and retna problems
due to diabetic complications. Are they saying that this an
additional
benefit?

BJ
--
"I find that the harder I work, the more luck I seem to have."
-- Thomas Jefferson

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