Re: Homocysteine

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On Tue, 14 Mar 2006 21:58:37 -0500, Dennis R
<dennis.rekuta@xxxxxxxxxxxx> wrote:

Thanks Quentin, this gives me some homework. In light of the findings of
this study, I am interested to see the results of a similar study that I
just started. Although the initial stage just finished, last month I
joined a five year extension. The study is known as FAVORIT, and is
studying a similar combination of vitamins in a smaller sub-group of
patients than those in the general population, which the study just
released in the N.E.J.M. covered. FAVORIT covers only renal transplant
patients, who are at greater risk than the general population for
cardiovascular morbidity.

The prospective study of renal patients in Australia that preceded
FAVORIT indicated that: "After adjustment for several important risk
factors, elevated tHcy levels (>/=12 micromol/L) were associated with
2.44 times the mortality risk of patients with normal tHcy levels"
"Similarly, elevated tHcy levels were associated with 1.63 times
increased risk of kidney allograft loss"

Fasting Plasma Total Homocysteine Levels and Mortality and Allograft
Loss in Kidney Transplant Recipients: A Prospective Study
Winkelmayer WC, Kramar R, Curhan GC, et al
Journal of the American Society of Nephrology. 2005;16(1):255-260

Whether I get the placebo or 1 of 2 doses of vitamins, hopefully the
study will show that at least some people get some benefit in reducing
homocysteine levels.

http://www.niddk.nih.gov/patient/favorit/favorit.htm

Dennis (Type 2, Kidney Transplant 1995)

G'day G'day Dennis,

Thank you for posting. The pharmacology associated with homocysteine
is in its infancy so it is important not to let negative results
discourage further research.

Homocysteine appears as a marker in so many pathological conditions it
seems that time will show it is important to deal with it. My guess
is that in time we discover WHAT ELSE must be done get the benefits of
lowering homocysteine.

Best wishes,

--
Quentin Grady ^ ^ /
New Zealand, >#,#< [
/ \ /\
"... and the blind dog was leading."

http://homepages.paradise.net.nz/quentin
.

Relevant Pages

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