Re: Doing everything right but the numbers are going up

x-no-archive: yes

Just wrote:

If fully agree with what you say, but I still don't understand how it
proves that a whole lot of bad stuff happens under 140.



I've previously posted cites demonstrating beta cell damage at 100 and up.

Peripheral neuropathy is so common with IGT that it's impossible to google it up or search it on Medline without finding an abundance of articles about the need to treat pre-diabetes to prevent it.

Pre-diabetes and neuropathy

http://millercenter.uchicago.edu/learnaboutpn/typesofpn/diabetes/prediabetes.shtml

http://www.med.umich.edu/pfund/dart.htm#und


Electromyogr Clin Neurophysiol. 2005 Jun;45(4):241-4.
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Early peripheral nerve abnormalities in impaired glucose tolerance.

Cappellari A, Airaghi L, Capra R, Ciammola A, Branchi A, Levi Minzi G, Bresolin N.

Service of Clinical Neurophysiology, Dino Ferrari Centre, Department of Neurological Sciences, IRCCS Ospedale Maggiore di Milano and University of Milan, Milan, Italy. albertocapp@xxxxxxxx

Increased prevalence of impaired glucose tolerance (IGT) has been recently detected in patients with painful sensory neuropathy. To determine whether nerve abnormalities are present in IGT we investigated IGT subjects without clinical neuropathy. Nerve conduction studies (NCS) were performed in 12 subjects with IGT without symptoms and signs of neuropathy. The results were compared with those obtained from 12 patients with type 2 diabetes (DM) without clinical neuropathy and 12 healthy controls. Sensory NCS of the sural nerve were performed on different segments, the distal-leg (10 cm proximal to the lateral malleolus) and the proximal-leg segment (10 cm more proximal). The distal conduction velocity of the sural nerve was increased in IGT subjects, compared both to healthy controls and DM patients. No difference was found among the groups with respect to the sensory conduction velocity of the sural nerve fibers in the proximal-leg segment. A reduction of both distal and proximal amplitudes of the sural nerve action potentials was detected in DM patients compared with IGT subjects and controls. The abnormal conduction velocity in the distal segment of the sural nerve, observed in IGT subjects without clinical neuropathy, suggests that the myelin dysfunction of the distal sensory fibers represents the earliest detectable nerve response to the hyperglycemia. The reduced amplitude of the sural nerve action potential in asymptomatic patients with DM arises from the axonal degeneration and represents a more advanced stage of nerve disease.

PMID: 16083148 [PubMed - indexed for MEDLINE]

Neurology. 2003 Jan 14;60(1):108-11.
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Comment in:
• Natl Med J India. 2004 Jul-Aug;17(4):206.

The spectrum of neuropathy in diabetes and impaired glucose tolerance.

Sumner CJ, Sheth S, Griffin JW, Cornblath DR, Polydefkis M.

Department of Neurology, The Johns Hopkins University, Baltimore, MD, USA.

OBJECTIVE: To compare the neuropathy associated with impaired glucose tolerance (IGT) and diabetes mellitus (DM) determined by oral glucose tolerance testing (OGTT). METHODS: Patients with peripheral neuropathy of unknown cause were prescribed OGTT. Duration of neuropathic symptoms, neuropathic pain, neuropathy classification, nerve conduction test results, and intraepidermal nerve fiber densities (IENFD) were compared between IGT and DM groups. RESULTS: Seventy-three patients completed OGTT; 41 (56%) had abnormal results. Of these 41 patients, 26 had IGT and 15 had DM. Patients with IGT had less severe neuropathy than patients with diabetes, as measured by sural nerve amplitudes (p = 0.056), sural nerve conduction velocities (p = 0.03), and distal leg IENFD (p = 0.01). Patients with IGT had predominantly small fiber neuropathy, compared to patients with DM (p = 0.05), who had more involvement of large nerve fibers. CONCLUSIONS: The neuropathy associated with IGT is milder than the neuropathy associated with DM. Small nerve fibers are prominently affected and may be the earliest detectable sign of neuropathy in glucose dysmetabolism. OGTT is appropriate in patients with idiopathic neuropathy.

Publication Types:
• Clinical Trial

PMID: 12525727 [PubMed - indexed for MEDLINE]


Susan
.

Relevant Pages

  • Peripheral Neuropathy-Amalgams-Nervous System
    ... Mononeuropathy = disease of a single nerve ... Carpal Tunnel or other diseases that cause entrapment of the nerve, ... Hemorrhage; Exposure to cold or radiation; Lack of blood supply ... >What is Peripheral Neuropathy? ...
    (sci.med.dentistry)
  • Re: Support Doctors, Pharmaceuticals, USDA Food Pyramid; Eat Your Wheaties!
    ... GLUTEN SENSITIVITY IS PREVALENT IN PATIENTS WITH PERIPHERAL ... Gluten sensitivity in patients with neuropathy was more frequent than ... The prevalence of gluten-sensitive enteropathy is ...
    (sci.med.nutrition)
  • Re: EMGs suck!!!! :)
    ... If it goes away, it ain't neuropathy. ... bg control, good diet, vitamins and supplements, etc, - but pain control, ... far as nerve cell death it is irreversible. ... diabetes, then since diabetes is irreversible, you'll never be able to ...
    (alt.support.diabetes)
  • Re: EMGs suck!!!! :)
    ... If it goes away, it ain't neuropathy. ... bg control, good diet, vitamins and supplements, etc, - but pain control, ... far as nerve cell death it is irreversible. ... diabetes, then since diabetes is irreversible, you'll never be able to ...
    (alt.support.diabetes)
  • Re: Lifestyle Changes Regenerate Nerve Fibers in Prediabetics
    ... In patients with diabetes, nerve fiber damage that causes diabetic ... blood glucose levels slows the risk of neuropathy, ... Dr. Smith and his associates, from the University of Utah in Salt Lake City, ...
    (alt.support.diabetes)