Symlin was Re: Insulin for Non-insulin type 2 diabetics

Jefferson wrote:
Amylin Replacement With Pramlintide in Type 1 and Type 2 Diabetes: A Physiological Approach to Overcome Barriers With Insulin Therapy -
http://clinical.diabetesjournals.org/cgi/content/full/20/3/137


This article is well worth a read! Thanks for posting the link.

One thing that I have not gotten clear in my mind is the functional difference between Symlin and Byetta (what changes one makes that the other does not).

I've gotten the impression that endos think Symlin should be given to Type 1s and Byetta to type 2s. My doctor was all over me to try Byetta, but that was before I discovered I have a type 1 response to insulin. I'm going back to see her in a few weeks, and because I'm still having trouble with my post-meal numbers even with the basal working, I've been wondering which of these drugs (if any) would be the right one for me.

Both seem to slow gastric emptying, increase weight gain, and lower blood sugar--when they work. Byetta apparently stimulates the beta cells. Since I experienced response to Starlix that also does that, I'm tending to think Symlin would be better. But the problem for me could be that it causes hypos.

Anyone have any ideas about this?



--Jenny

http://www.phlaunt.com/diabetes Diabetes Info

http://www.alt-support-diabetes.org/newlydiagnosed.htm Get Your Blood Sugar Under Control
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Relevant Pages

  • Re: Symlin was Re: Insulin for Non-insulin type 2 diabetics
    ... I've gotten the impression that endos think Symlin should be given to Type 1s and Byetta to type 2s. ... Symlin, generic name pramlintide acetate, is a synthetic amylin; Byetta, generic name extenitide, is a synthetic version of GLP-1. ... The GLP-1 hormone has the effect of telling the pancreas that an increase in glucose is on the way, so start releasing insulin. ...
    (alt.support.diabetes)
  • Re: Symlin was Re: Insulin for Non-insulin type 2 diabetics
    ... I've gotten the impression that endos think Symlin should be given to ... Type 1s and Byetta to type 2s. ... but that was before I discovered I have a type 1 response to insulin. ... Amylin Pharmaceuticals, and that they have some overlapping mechanisms. ...
    (alt.support.diabetes)
  • Re: Symlin was Re: Insulin for Non-insulin type 2 diabetics
    ... That is by far the most cogent explanation of how Symlin and Byetta work that I've seen anywhere! ... Byetta, when it works, seems to work dramatically, but it is not at all clear to me if it is mainly because it forces people to cut way back on the foods that push up blood sugar. ... The GLP-1 hormone has the effect of telling the pancreas that an increase in glucose is on the way, so start releasing insulin. ... The amount of insulin release is modulated by the BG, so this is of special interest to Type-2s. ...
    (alt.support.diabetes)
  • Re: Byetta
    ... I used it six months prior to going on the pump, at which time Dr. Endo switched me to Sister ... appetite I had lost while on the Byetta (not as much bg success, ... because I seem to lack the cells it needs, whereas, the Symlin has my pp bg down to the 90's, ... there are two good email groups for Byetta users. ...
    (alt.support.diabetes)
  • Re: Insulin Poll - Dosing?
    ... My endo doctor thinks a pump or Symlin ... My insulin supplies are free at ... who are on Byetta ...
    (alt.support.diabetes)