Re: OK got the results

Hi Susan and Evelyn:

Evelyn Ruut wrote:

Been taking Pantethine for three months 300 mg Jarrows every night. No change in my cholesterol at all, not even a couple of points. Doc is insisting I need to go on Pravachol because he says it has less of the side effects that made me so miserable with the other ones.

Unfortunately I guess I am not one of the lucky ones for whom this supplement works.


Evelyn, the dose in the research that I took for excellent results was 450mg twice per day. I don't think you gave it an adequate trial. There's nothing to say you couldn't take even more than that, but nothing to say that the dose you took is effective.


 I will probably keep on taking it since I have it anyway,

and perhaps it will be beneficial in some way, but the numbers did not bear out the expectations. 


You didn't take the well studied therapeutic dose.  :-(

I won't tell you what you should do, but I will say that there's no good reason to believe pantethine has failed you.

I hope you'll consider trying to up the dose, it's atoxic even in end stage renal and hepatic patients.

I know that Susan has posted numerous references to pantethine in the past. I did a scholar.google.com search using pantothenic+cholesterol+ human+dose and came up with 533 finds - http://tinyurl.com/boo88.

I also know of a person that doses at Pantothenate (B5), 7.6 gm/day and has done so for some time. He is a big man - about 6' 6" tall and 207 pounds (2.04m height, 94kg weight). If he had a problem with toxicity using pantothenate it would have cropped up already. I am not suggesting this man's dosage, but just citing it as a case in point of an extreme dose.

Evelyn: I notice in another post in this thread that you take CoQ10.

"CoQ10—A Brief Review
Food sources of CoQ10 include beef heart, sardines, anchovies,mackerel,
salmon, broccoli, spinach, and nuts. Although CoQ10 can be obtained from
these foods (only about 3-5 mg per day), it would require consuming
large quantities to be the equivalent of taking a CoQ10 supplement. CoQ10 is biosynthesized from tyrosine through a cascade of aromatic precursors, which indispensably require certain vitamins: vitamins B2, B6, B12, folic acid, niacin, pantothenic acid, and vitamin C. CoQ10 functions as a carrier to transfer electrons across the membrane of mitochondria (the energy generator in the body’s cells) to drive the production of adenosine triphosphate (ATP), the fuel that energizes cells in our body. Heart muscle cells have the greatest concentration of
mitochondria—5,000 per cell. Prior to supplementation, the basal plasma
CoQ10 concentration in healthy individuals has been reported in
various studies to range from 0.3 µg/ml to 1.0 µg/ml. A decrease in
the levels of coenzyme Q10 in our bodies is associated with aging and
as a result of certain medications, such as statin drugs."

Frank


.

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