Re: My feet remind me that I have diabetes

"CeeBee" <ceebeechester@xxxxxxxxxxxx> wrote in message
news:Xns9718B37A6A823ceebeechesterstartco@xxxxxxxxxxxxxxxx
> "Ozgirl" <are_we_there_yet@xxxxxxxxxx> wrote in alt.support.diabetes:
>

<snip>

> It's clear that there is a link between uncontrolled high BG's and an
> increased _risk_ for developing diabetic complication, but the mechanism
> how
> and when those complications exactly occur is largely unknown.

Hi CeeBee ,
if you have high blood glucose than more glucose is transported into the
cell.Also into the nerve cell. In the cell glucose is converted into
sorbitol by an enzyme , an aldose reductase.Now there are active glucose
transporters but there are no known active sorbitol transporters. The
sorbitol will build up in the nerve cell because it can not cross the cell
membrane and it is not transported outside the cell. This causes what is
known as osmotic pressure , caused by pure physics : the transport of water
into the cell. The nerve cell is damaged by the water pressure inside the
cell.It will cause pain.

Pharmaceutical companies are now working on aldose reductase inhibitors for
relief of PN

http://www.paralumun.com/diabetesaldose.htm

http://www.lifescan.com/professionals/hcp/news/20050316clin004/

http://jcp.sagepub.com/cgi/content/abstract/34/7/760

hth
Gys


.

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