Re: ideas why Metformin isn't preforming please?
- From: nospam6@xxxxxxxxxxxxxx
- Date: 3 Nov 2005 04:24:26 -0800
tog wrote:
> I started taking Metformin 2x500 beginning of September. My monthly fbg
> reading before.. averaged out to 6.5. 1hr after dinner 8.1
6.5 mmol/L (120 mg/dL) average fasting BG is not bad.
8.1 mmol/L (150 mg/dL) as an average 1 hr postprandial is not bad
either.
What was your average 2 hr postprandial ?
More importantly... what was your HgbA1C ??
> 6 weeks later, experiencing no side effects, my bgs showed hardly any
> change..I upped it to 3x500...as an experiment.
Not surprising. Metformin typically adds very little to already decent
BG control especially when carbs have been largely removed as you
describe below.
> 1x 500 Metformin with breakfast (1 scrambled egg).. Lunch is normally 1
> ryvita with cheese and salmon..1x 500 Metformin with dinner (meat, veggies
> and a occasional small portion of potatoes) 1 yoghurt midmorning and
> afternoon as snacks. The last 1x500 Metformin I take at bedtime with a glass
> of wine and a few nuts.
You have just provided a good description of **what** you are eating.
Only by providing meal weights, will you provide a good account of
**how much** you are eating.
> I've dropped all breads, cereals..pasta and rices..
Then, you are low-carbing, which means that the elevated BG you are
measuring is coming from gluconeogenesis by the liver which is doing
this through utilizing the amino acids coming from the breakdown of
muscle.
> I do treat myself to 3
> coffees per day with half teasp of sugar.. (sugar substitutes taste too
> awful)
That bit of sugar will be insufficient to prevent muscle breakdown.
> Now at the 8 week point, Im averaging out to fbg 6.3 1hr after dinner 7.5
> I'm sure the diet changes and added exercise alone should of made a bigger
> drop. Any ideas why the Metformin isn't preforming please?
Metformin will have its biggest effect for those whose underlying
problem is insulin resistance in the face of excessive carb intake.
For those whose underlying problem is largely failing beta islet cells
despite low carb intake, metformin will have minimal impact on serum BG
levels. Folks in the latter category are more type 1 than type 2.
Hope the above information helps you, Sue.
The Lord Whom I love and serve is the source of this and all other
knowledge. To Him belongs all the glory :-)
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