How Chronic Pain Gets Into Your Head
- From: "JoeZ" <JoeZ@xxxxxxxx>
- Date: Tue, 29 Nov 2011 21:55:12 -0500
How Chronic Pain Gets Into Your Head...
For many, the impact of chronic pain may not be limited to the pain itself;
could also negatively affect their mental state.
New research by scientists at Northwestern University in Chicago may
explain why people who have chronic pain also suffer from seemingly
unrelated problems such as depression, anxiety, lack of sleep and trouble
"The pain is in your head," said Dr. Dante Chialvo, lead author of the study
and associate research professor of physiology at the Feinberg School of
Medicine. "The whole head."
The study showed that people with chronic pain have a portion of the brain
that is always active: the region associated with mood and attention. This
constant activity rewires nerve connections in the brain and leaves chronic
pain sufferers at greater risk for mental problems.
Chialvo said that a healthy brain exists in a state of equilibrium, with
the same number of regions turned on and off. As certain regions are
recruited for various tasks, other regions turn off to maintain the
But a person in chronic pain is not so even-keeled.
"We knew there are important differences in behavior in [chronic pain]
patients," Chialvo said. "That has to come from brain abnormalities."
Chialvo described chronic pain as an idea that gets stuck in your head. The
brain may not be able to attend to other tasks as well or as quickly because
is preoccupied with the pain signals.
Chialvo suggested that receiving pain signals constantly can result in
rewiring that negatively affects the brain, and in particular, the regions
associated with attention and mood. The rewiring forces their brains to
allocate mental resources differently to cope with everyday tasks - from
mathematics, to recalling a shopping list, to feeling happy.
The pain-brain connection has been well documented, at least anecdotally,
and many doctors say they have seen firsthand how a patient's mental state
can go downhill when they suffer chronic pain.
"Disordered sleep, less mental focus, mood irritability, and even depression
with less overall joy and enthusiasm for life are what I see in this patient
population," Dr. Doris Cope, professor and vice chairman of pain medicine at
the University of Pittsburgh Medical Center's Pain Medicine Program.
Such may be the case with John Cannon, 70, who has had chronic low back
pain for 40 years and says it takes him quite a while to fall asleep.
"There are nights that are better than others," he said. "It will take me a
to get into a comfortable position to go to sleep. . I just learned to
Cannon, who is a participant in Chialvo's study, said he tries to not let
pain affect his life drastically, but in some situations, he wishes it
"I do most things that I always do but I do them more slowly. . I know I'm
going to pay the price if I lift [heavy things]. You get over those things,
Misconceptions about the pain-brain connection may have arisen from a lack
of evidence that pain has a measurable, lasting impact on the brain.
But Chialvo believes his research finally quantifies the connection. His
group's experiment monitored patients' brains while they tracked a moving
object on a computer screen, a task that required minimal attention. Chialvo
and his group found that patients with chronic pain had 50 times as many
active regions in their brains than their pain-free counterparts.
Page 2 of 2
Feb. 6, 2008
"We are providing objective evidence that is not a first person report; this
third-person report," Chialvo said. "There is something inside the patient's
head, which is different, and we should pay attention."
Pain for Life?
But some are not convinced that these brain changes are as lasting as
and his group suggest.
"It really is the 'chicken and the egg' question," said Dr. John Wilson,
residence program director for the department of neurosurgery at the Wake
Forest University School of Medicine. "It may well be that this type of
underlying brain dysfunction was present in this group of patients to start
with and predisposed this group of patients to develop a chronic pain
Others point out that the study did not report whether patients were taking
pain medication, nor did it discuss how the brain may change over time if a
patient were to experience less pain through rehabilitation.
"There is no question that changes occur. The question relates to
permanency," said Dr. Joshua Prager, director of the Center for the
Rehabilitation of Pain Syndromes (CRPS) at UCLA Medical Plaza. "I see
people come back to life and become who they were. When they had pain
they were not who they were."
Still, Chialvo hopes that with further research into the mechanism of how
chronic pain makes people more susceptible to mood disorders, people will be
able to improve their quality of life. Cognitive therapy and other
that teach people how to distract from their pain may help them as well.
"Maybe if we treat the consequences, their quality of life will be better
they forget about the pain," Chialvo said. "If you are better prepared to
you are always better."
read this please.... jz
sounds about right but most people coping skills differ so this is not very
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