Re: Pointless BS Deleted

On Jun 3, 5:37 pm, Rusty the Spamming Retarded Dickwadd
<flakey...@xxxxxxxxxxxxx> wrote:snip <<


You were TOLD to stay off my threads ..

Giiiiiit .. you fkg .. atheist .. shteater ..

DOOOOO .. it .. you dysfunctional .. mutated ..
shteating .. atheist .. freak ..


-------------------


"Oral lecithin is more effective than of choline chloride"


Acute toxicity assessment of choline by inhalation, intraperitoneal
and oral routes in Balb/c mice.Mehta AK, Arora N,
Regul Toxicol Pharmacol. 2009 May 18.
Gaur SN, Singh BP.
Allergy and Immunology Section,
Institute of Genomics and Integrative Biology, Delhi-110007.;
Department of Biotechnology, University of Pune, Pune-411007.


Studies suggest that choline has potential to be used as a dietary
supplement and a drug for immune inflammatory diseases like
asthma and rhinitis.
But there are apprehensions regarding adverse effects of choline
when given orally in high doses.
To address this knowledge gap, toxicity assessment of choline
chloride was carried out by intranasal (i.n.), oral and
intraperitoneal (i.p.) routes in Balb/c mice for 28 days.
Body weight, food and water consumption of mice were recorded daily.
Haematology and clinical chemistry were assessed to check
hepatocellular functions and morphological alterations of the cells.
Splenocyte counts were analysed for evaluating cellular immunity.
Liver function test was performed by assaying different enzyme
systems in serum such as, urea, blood urea nitrogen (BUN),
creatinine, alanine aminotransferase (ALT), and aspartate
aminotransferase (AST).
Body weight, food and water consumption did not differ between
mice treated with choline and the saline control group.
Hematologic and biochemical variables were not affected with any
increase in serum toxicity marker enzymes indicating normal liver
functioning.
Choline administration did not affect total cholesterol and high
density lipoprotein levels as compared to their respective controls.
Urea and blood urea nitrogen levels in choline treated mice were not
different than controls.
Creatinine level was however, higher than control in i.p. treatment
group, but other parameters were normal.
In conclusion, the repeated consumption of choline chloride via i.n.
and oral or i.p. routes did not cause toxicity in mice in the
toxicological endpoints examined.


PMID: 19460409


-------------­-----


"Lecithin may therefore be the method of choice for
accelerating acetylcholine synthesis"


Lecithin consumption raises serum-free-choline levels.
Lancet. 1977 Jul 9;2(8028):68-9.
Wurtman RJ, Hirsch MJ, Growdon JH.


Consumption of choline by rats sequentially increases serum-choline,
brain-choline, and brain-acetylcholine concentrations. In man
consumption of choline increases in levels in the serum and
cerebrospinal fluid; its administration is an effective way of
treating tardive dyskinesia.
We found that oral lecithin is considerably more
effective in raising human serum-choline levels than an equivalent
quantity of choline chloride. 30 minutes after ingestion of choline
chloride (2-3 g free base), serum-choline levels rose by 86% and
returned to normal values within 4 hours; 1 hour after lecithin
ingestion, these levels rose by 265% and remained significantly
raised for 12 hours.
Lecithin may therefore be the method of choice for
accelerating acetylcholine synthesis by increasing the availability
of choline, its precursor in the blood.


PMID: 69151


------------


"Non-addictive Choline reduces the regular dose of aspirin or
morphine"


Antinociceptive effects of choline against acute and inflammatory
pain.
Wang Y, Su DM, Wang RH, Liu Y, Wang H.
Thadweik Academy of Medicine, Beijing 100850, PR China.


We used the hot plate test and the formalin test to evaluate
the antinociception of choline after i.c.v. or i.v. administration.
The analgesic mechanism of choline was also studied.
The response latency of mice was significantly prolonged in the
hot plate test after choline (90-120 mug/animals) i.c.v.
administration in a dose-dependent manner.
Pretreatment with methyllycaconitine citrate (MLA),
alpha-bungarotoxin, or atropine blocked the antinociception of
choline in the hot plate test.
In contrast, mecamylamine and naloxone had no effect.
No antinociceptive action of choline was found in the hot plate test,
but it did have an effect in the late phase of the formalin test
after
i.v.
administration.
The effect of choline on anti-inflammatory pain was blocked by MLA,
but not by mecamylamine, naloxone and atropine, which is indicative
of the involvement of alpha7 receptors in peripheral sites.
When choline (2 mg/kg) was coadministered with aspirin (9.4 mg/kg),
the licking/biting times in the late phase significantly decreased,
although no effects were shown when these doses of drugs were used
alone.
Similarly, coadministration of choline (2 mg/kg) with morphine
(0.165 mg/kg) significantly increased the antinociception of morphine
in the late phase, but had no effect in the early phase.
These results demonstrate that activation of alpha7 nicotinic
receptors
by choline elicits antinociceptive effects both in an acute thermal
pain
model and in an inflammatory pain model.
Choline holds promise for development as a non-addictive analgesic
drug and in reducing the regular dose of aspirin or morphine in
inflammatory pain.


PMID: 15780465


------------


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

.

Quantcast