- From: "Mike Easter" <MikeE@xxxxxxxxxxxx>
- Date: Mon, 22 Dec 2008 12:20:19 -0800
<sortofa cross between 'oops' and 'hmmmm'>
Mike Easter wrote:
The first thing that struck me when I first gave the label itself a
look over was the phrase "for oral or rectal administration". I told
myself it was a typo and ripped the Rx'ing info packet off the bottle.
If you had a laxative which was labeled oral or rectal, it wasn't
lactulose, but some other laxative, I don't know what.
Searching on lactulose + 'orally or rectally' I find^1 some product lines
so labeled. I think rectal admin of lactulose isn't a good choice of a
Lactulose must be administered orally because of its mechanism of
action. It is an osmotic cathartic which requires intestinal transit to
achieve its effect, ie it won't work if administered rectally.
^1 http://www.77canadapharmacy.com/lactulose.php Lactulose MAY BE USED
ORALLY OR RECTALLY.
<but then the labeling directions provide no rectal administration
I /am/ finding some research studies in which lactulose was admin/ed
rectally to some hepatic encephalopathy patients as a treatment to achieve
pH change and ammonia trapping from the colon -- but that wasn't for its
I'm wondering if the labeling might be in error or at the very least a
"Lactulose is a colonic acidifier for treatment and prevention of
That is, lactulose could be sold as an oral laxative or a rectal/colonic
treatment for encephalopathy.