remicade and polymyalgia rheumatica - no improvement

The Incidence of Serious Infections is not Increased in Patients with
Rheumatoid Arthritis Treated with Anti-TNF Drugs Compared to Those
Treated with Traditional DMARDs: Results from a National Prospective
Study
Category: 18. RA treatment ? biologics and gene therapy
Title: Infliximab in the Treatment of Polymyalgia Rheumatica: A Double
Blind, Randomized, Placebo Controlled Study
Category: 32. Vasculitis
Author(s): Carlo Salvarani1, Carlo Manzini2, Giuseppe Paolazzi3, Aldo
Trotta4, Paolo Manganelli5, Marco Cimmino6, Roberto Gerli7,
Mariagrazia Catanoso1, Luigi Boiardi1, Giuseppe Germanò1, Pierluigi
Macchioni1, Fabrizio Cantini8. 1Arcispedale S Maria Nuova, Reggio
Emilia, Italy; 2Policlinico, Modena, Italy; 3Ospedale S Chiara,
Trento, Italy; 4Policlinico S Salvatore, L'Aquila, Italy; 5Ospedale
Maggiore, Parma, Italy; 6Ospedale S Martino, Genova, Italy;
7Policlinico Monteluce, Perugia, Italy; 8Ospedale di Prato, Prato,
Italy
Presentation Number: 1828
Purpose: To compare the efficacy and safety of prednisone plus
infliximab (IFX) and prednisone alone in patients with newly diagnosed
polymyalgia rheumatica (PMR).
Methods: Design: multicenter, double-blind, randomized, placebo-
controlled study. Setting: 7 Italian rheumatology clinics. Patients:
49 patients with newly diagnosed PMR (according to Healey?s criteria).
Primary endpoints: proportion of relapse-free patients through week
22. Relapse was defined as: a flare-up of signs and symptoms of PMR
accompanied by an increased erythrocyte sedimentation rate (> 30 mm/h)
levels and the concomitant increase in the patient?s dose of
corticosteroids (CS).

Conclusions: In this population of newly diagnosed PMR patients, IFX 3
mg/kg administered every 8 weeks after an induction regimen, did not
improve the proportion of relapse-free patients compared to placebo
through week 22. IFX was well tolerated in this cohort of elderly
patients.





Visit my website:
http://www.mzuschlag.com
.

Relevant Pages

  • Comparing groups of different sample sizes
    ... I am wanting to compare the difference in hospital length of stay and ... associated cost savings between a group of 167 patients whose ...
    (sci.stat.edu)
  • Re: Gynecologist Accused of Mutilating, Abusing Hundreds of Women
    ... patients, many other patients, have now come forward with horror stories, ... If the 'pride' merely involved removal of the clitoral hood, ... you simply can't compare an adult ...
    (alt.true-crime)
  • Purevision vs. Focus Night & Day?
    ... patients who have tried both, to hear how they compare. ... prescribed with monovision. ... with a multifocal silicone hydrogel in the near future? ...
    (sci.med.vision)
  • Re: Comparing groups of different sample sizes
    ... associated cost savings between a group of 167 patients whose ... can i compare the entire 800 as long as variances on key variables are ... They don't need to be equal - some common procedures assume equal ...
    (sci.stat.edu)