~*Online WACOC News 2006 June 26*~
- From: "DGSaba" <dgsaba@xxxxxxx>
- Date: 26 Jun 2006 08:47:18 -0700
Women and Children of CFIDS
WACOC
~*A comment or two*~
Would love to know exactly how many medical professionals became ill
after receiving the Hepatitis B Vaccines in the 1980's...
Bioresearch Online
Current Headlines
http://www.bioresearchonline.com/content/news/newsindex.asp?bucket=latest+headlines&VNETCOOKIE=NO
Researchers Map Infectious Hepatitis B Virus
6/23/06
Researchers Reverse Parkinson's Symptoms In Animal Models
6/23/06
PTPN22 Gene Associated With Both Susceptibility And Disease Progression
In Rheumatoid Arthritis
Also, this article is from 6/72002 Bioresearch Online
Fibromyalgia pain isn't all in the patients' heads, new brain study
finds
fMRI scans give first objective measure of mysterious ailment, provide
road map for future study
ANN ARBOR, MI - A new brain-scan study confirms scientifically what
fibromyalgia patients have been telling a skeptical medical community
for years: They're really in pain.
In fact, the study finds, people with fibromyalgia say they feel severe
pain, and have measurable pain signals in their brains, from a gentle
finger squeeze that barely feels unpleasant to people without the
disease. The squeeze's force must be doubled to cause healthy people to
feel the same level of pain - and their pain signals show up in
different brain areas.
The results, published in the current issue of Arthritis & Rheumatism,
the journal of the American College of Rheumatology, may offer the
proof of fibromyalgia's physical roots that many doubtful physicians
have sought. It may also open doors for further research on the
still-unknown causes of the disease, which affects more than 2 percent
of Americans, mainly women.
Lead authors Richard Gracely, Ph.D., and Daniel Clauw, M.D., did the
study at Georgetown University Medical Center and the National
Institutes of Health, but are now continuing the work at the University
of Michigan Health System. In an editorial in the same issue, Clauw and
U-M rheumatologist Leslie Crofford, M.D., stress the importance of
fibromyalgia research and care.
To correlate subjective pain sensation with objective views of brain
signals, the researchers used a super-fast form of MRI brain imaging,
called functional MRI or fMRI, on 16 fibromyalgia patients and 16
people without the disease. As a result, they say, the study offers the
first objective method for corroborating what fibromyalgia patients
report they feel, and what's going on in their brains at the precise
moment they feel it. And, it gives researchers a road map of the areas
of the brain that are most - and least - active when patients feel
pain.
"The fMRI technology gave us a unique opportunity to look at the
neurobiology underlying tenderness, which is a hallmark of
fibromyalgia," says Clauw. "These results, combined with other work
done by our group and others, have convinced us that some pathologic
process is making these patients more sensitive. For some reason, still
unknown, there's a neurobiological amplification of their pain
signals."
Further results from the study were presented last year at the ACR
annual meeting. The project will continue later this year at UMHS,
joining other fMRI fibromyalgia research now under way.
For decades, patients and physicians have built a case that
fibromyalgia is a specific, diagnosable chronic disease, characterized
by tenderness and stiffness all over the body as well as fatigue,
headaches, gastrointestinal problems and depression. Many patients with
the disease find it interferes with their work, family and personal
life. Statistics show that far more women than men are affected, and
that it occurs mostly during the childbearing years.
The ACR released classification criteria for fibromyalgia in 1990, to
help doctors diagnose it and rule out other chronic pain conditions.
Clauw and Crofford's editorial looks at the current state of research,
and calls for rheumatologists to take the lead in fibromyalgia care and
science.
But many skeptics have debated the very existence of fibromyalgia as a
clearly distinct disorder, saying it seemed to be rooted more in
psychological and social factors than in physical, biological causes.
Their argument has been bolstered by the failure of research to find a
clear cause, an effective treatment, or a non-subjective way of
assessing patients.
While the debate has raged, neuroscientists have begun to use brain
scan technology to identify the areas of the normal human brain that
become most active during pain. A few studies have even assessed the
blood flow in those areas in fibromyalgia patients during baseline
brain scans. The new study is the first to use both high-speed scanning
and a painful stimulus.
In the study, fibromyalgia patients and healthy control subjects had
their brains scanned for more than 10 minutes while a small,
piston-controlled device applied precisely calibrated, rapidly pulsing
pressure to the base of their left thumbnail. The pressures were varied
over time, using painful and non-painful levels that had been set for
each patient prior to the scan.
The study's design gave two opportunities to compare patients and
controls: the pressure levels at which the pain rating given by
patients and control subjects was the same, and the rating that the two
different types of participants gave when the same level of pressure
was applied.
The researchers found that it only took a mild pressure to produce
self-reported feelings of pain in the fibromyalgia patients, while the
control subjects tolerated the same pressure with little pain.
"In the patients, that same mild pressure also produced measurable
brain responses in areas that process the sensation of pain," says
Clauw. "But the same kind of brain responses weren't seen in control
subjects until the pressure on their thumb was more than doubled."
Though brain activity increased in many of the same areas in both
patients and control subjects, there were striking differences too.
Patients feeling pain from mild pressure had increased activity in 12
areas of their brains, while the control subjects feeling the same
pressure had activation in only two areas. When the pressure on the
control subjects' thumbs was increased, so did their pain rating and
the number of brain areas activated. But only eight of the areas were
the same as those in patients' brains.
In all, the fibromyalgia patients' brains had both some areas that were
activated in them but not in controls, and some areas that stayed
"quiet" in them but became active in the brains of controls feeling the
same level of pain. This response suggests that patients have enhanced
response to pain in some brain regions, and a diminished response in
others, Clauw says.
The study was supported in part by the National Fibromyalgia Research
Association, the U.S. Army and the NIH. In addition to Clauw and
Gracely, the research team included Frank Petzke, M.D.; and Julie M.
Wolf, BA. For more information on fibromyalgia research at UMHS, visit
www.med.umich.edu/intmed/rheumatology/fmweb.
Source: U-M Health System Public Relations
http://www.bioresearchonline.com/content/news/article.asp?docid={b88e912b-7896-11d6-a789-00d0b7694f32}&VNETCOOKIE=NO
Soft hugs to those who need them!
Research holds all our answers
Praying for world peace
How does a human heart hurt so deeply and still survive is beyond ME
CFIDS FM...
Enjoy the sunsets and sunrises,
Diana Saba
Retired Nurse
FM ME/CFIDS
Related Neurological Disorders
CDC's Wm Reeves Must Go
Bring Back the GAO
Where did over 4 Million $'s of misappropriated funds go to?
CDC website linked NCF link to Porn ~ Why?
Grassroots Action for Myalgic Encephalomyelitis / Chronic Fatigue
Syndrome
http://www.co-cure.org/Congressional_Action.htm
Please Support NCF's Research Plans
http://www.ncf-net.org/
http://www.ncf-net.org/Discoveries.htm
Please Sign Petitions
http://www.petitiononline.com/MEitis/petition.html
http://www.petitiononline.com.cfs2004/
May 12th Awareness Day
http://www.geocities.com/capitolhill/4277/
The One Campaign
http://www.one.org/
The HHV-6 Site
http://hhv6.freeservers.com/
Betrayal By the Brain:
The neurological basis of chronic fatigue syndrome, fibromyalgia
syndrome and related neural network disorders.
by Dr. Jay A Goldstein
http://home.vicnet.net.au/~mecfs/general/goldstein_summary.html
CFSAC Meeting Presentation ~ June 21, 2004
http://listserv.nodak.edu/scripts/wa.exe?A2=ind0407a&L=co-cure&F=&S=&P=541
~*I truly hope the January 2006 CFSAC meeting will be addressing our
continued efforts and concerns about our nations blood supply and FM
ME/CFIDS and all related neurological disorders*~
The January 10, 2006 CFSAC meeting did not take place
http://www.hhs.gov/advcomcfs
FM ME CFIDS Information Forum
Co-Cure Archives
http://listserv.nodak.edu/archives/co-cure.html
TCJRME
http://www.geocities.com/tcjrme/
Reading, Researching, Posting to AMF
1997-2006
http://hometown.aol.com/dgsaba/myhomepage/profile.html
Type AMF Abusers into the google search engine box.
http://groups.google.com/group/alt.med.fibromyalgia/search?q=AMF+Abus...
Be safe not sorry...
"What lies behind us and what lies before us, are tiny matters,
compared to what lies within us" ~ Ralph Waldo Emerson
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