Must-have virus/spyware/maleware programs?

I have a collection of programs I run every weekend in hopes of
protecting my system. To those who are real knowledgeable about these
things, is this adequate or should I have something else I may be
unaware of, or am I overdoing it?

Here is what I run:

Nod32
A-Squared
AVG-anti rootkit-free
AVG anti-spyware (formerly Ewindo)
CCleaner
Clean-up
Webroot's SpySweeper
Spyware Terminator
Spyware Blaster

and occasionally:

Evidence Eliminator
CyberScrup Privacy Suite
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Does this seem like a good defense or am I being overly paranoid?

Anthony
.

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